We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Osteogenesis imperfecta (OI) is a phenotypically and genetically heterogeneous skeletal
dysplasia characterized by bone fragility, growth deficiency, and skeletal deformity …

The vertebrate collagen superfamily now includes over 50 collagens and collagen-like
proteins. Here, their different structures are described, as well as their diverse forms of …

A decade ago, bone morphogenetic protein 1 (BMP1) was shown to provide the activity
necessary for proteolytic removal of the C-propeptides of procollagens I–III: precursors of the …

Abstract Bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases, here called BTPs,
include the proteases originally identified for their roles in the C-terminal maturation of …

The astacin family (M12A) of the metzincin subclan MA (M) of metalloproteinases has been
detected in developing and mature individuals of species that range from hydra to humans …

The interaction between muscle tissues and bone metabolism is incompletely understood.
We hypothesized that there might be some humoral factors that are produced in muscle …

Purpose: The mechanical effect of raised intraocular pressure is a recognised stimulus for
optic neuropathy in primary open angle glaucoma (POAG). Characteristic extracellular …

The insulin/IGF-1 signaling (IIS) regulates a wide range of biological processes, including
aging and lifespan, and has also been implicated in the pathogenesis of Alzheimer9s …

Ossification of the posterior longitudinal ligament (OPLL) is a multi-factorial disease
involving an ectopic bone formation of spinal ligaments. It affects 0.8-3.0% aging Asian and …