A comparative analysis of synthetic genetic oscillators

O Purcell, NJ Savery, CS Grierson… - Journal of The …, 2010 - royalsocietypublishing.org
Synthetic biology is a rapidly expanding discipline at the interface between engineering and
biology. Much research in this area has focused on gene regulatory networks that function …

Discovering functions and revealing mechanisms at molecular level from biological networks

S Zhang, G Jin, XS Zhang, L Chen - Proteomics, 2007 - Wiley Online Library
With the increasingly accumulated data from high‐throughput technologies, study on
biomolecular networks has become one of key focuses in systems biology and …

[图书][B] Biomolecular networks: methods and applications in systems biology

AY Zomaya, Y Pan - 2009 - books.google.com
Alternative techniques and tools for analyzing biomolecular networks With the recent rapid
advances in molecular biology, high-throughput experimental methods have resulted in …

Theory of hybrid dynamical systems and its applications to biological and medical systems

K Aihara, H Suzuki - … Transactions of the Royal Society A …, 2010 - royalsocietypublishing.org
In this introductory article, we survey the contents of this Theme Issue. This Theme Issue
deals with a fertile region of hybrid dynamical systems that are characterized by the …

Controllability analysis of networks

A Lombardi, M Hörnquist - Physical Review E—Statistical, Nonlinear, and Soft …, 2007 - APS
The concept of controllability of linear systems from control theory is applied to networks
inspired by biology. A node is in this context controllable if an external signal can be applied …

[图书][B] Modeling biomolecular networks in cells: structures and dynamics

L Chen, R Wang, C Li, K Aihara - 2010 - books.google.com
Taking ideas from nature has been a theme of humanity's technological progress but it is
only our newfound expertise in molecular manipulation and complex nonlinear dynamics …

Intrinsic and extrinsic noise of gene expression in lineage trees

P Thomas - Scientific reports, 2019 - nature.com
Cell-to-cell heterogeneity is driven by stochasticity in intracellular reactions and the
population dynamics. While these sources are usually studied separately, we develop an …

Alignment of molecular networks by integer quadratic programming

Z Li, S Zhang, Y Wang, XS Zhang, L Chen - Bioinformatics, 2007 - academic.oup.com
Motivation: With more and more data on molecular networks (eg protein interaction
networks, gene regulatory networks and metabolic networks) available, the discovery of …

Modeling synthetic gene oscillators

EL O'Brien, E Van Itallie, MR Bennett - Mathematical biosciences, 2012 - Elsevier
Genetic oscillators have long held the fascination of experimental and theoretical synthetic
biologists alike. From an experimental standpoint, the creation of synthetic gene oscillators …

Noise-induced cooperative behavior in a multicell system

L Chen, R Wang, T Zhou, K Aihara - Bioinformatics, 2005 - academic.oup.com
Motivation: All cell components exhibit intracellular noise on account of random births and
deaths of individual molecules, and extracellular noise because of environment …