Quinoxaline as ubiquitous structural fragment: an update on the recent development of its green synthetic approaches

A Patel, D Shah, N Patel, K Patel, N Soni… - Current Organic …, 2021 - ingentaconnect.com
Quinoxaline is a versatile heterocyclic moiety that possesses a wide range of biological
activities. Therefore, many researchers have been performing the synthesis of quinoxaline …

Heterocyclic scaffolds for the treatment of Alzheimer's disease

A Martorana, V Giacalone, R Bonsignore… - Current …, 2016 - ingentaconnect.com
Background: The treatment and diagnosis of Alzheimer's Disease (AD) are two of the most
urgent goals for research around the world. The cognitive decline is generally associated …

Quinoxaline nucleus: a promising scaffold in anti-cancer drug discovery

AC Pinheiro, TC Mendonça Nogueira… - Anti-Cancer Agents …, 2016 - ingentaconnect.com
Heterocyclic compounds are a class of substances, which play a critical role in modern drug
discovery being incorporated in the structure of a large variety of drugs used in many …

An “all-water” strategy for regiocontrolled synthesis of 2-aryl quinoxalines

B Tanwar, P Purohit, BN Raju, D Kumar, DN Kommi… - RSC Advances, 2015 - pubs.rsc.org
A new synthetic strategy of tandem N-aroylmethylation-nitro reduction–cyclocondensation
has been developed for the first and generalized regioselective synthesis of 2-aryl …

An expedient sequential one-pot four component synthesis of novel steroidal spiro-pyrrolidine heterocycles in ionic liquid

D Gavaskar, ARS Babu, R Raghunathan, M Dharani… - Steroids, 2016 - Elsevier
A facile one-pot synthesis of novel steroidal dispiro-indenoquinoxaline pyrrolidines via
multicomponent-[3+ 2]-cycloaddition of azomethine ylides in ionic liquid is described. The …

Synthesis and Biological Evaluation of Some N-Substituted Quinoxaline Derivatives as Antitumor Agents

AA Gobouri - Russian Journal of Bioorganic Chemistry, 2020 - Springer
A new hybrid molecules containing 1-(N-substituted)-quinoxaline derivatives were
synthesized from condensation of 3-hydroxy-2-oxo quinoxaline with 2, 3-unsaturated …

Synthesis, Docking, and Evaluation of Antimicrobial Activity of a New Series of Acyclo C‐Nucleosides of 1, 2, 4‐Triazolo[4, 3‐a]quinoxaline Derivatives

MS Ayoup, HEA Ahmed, AM El Massry… - Journal of …, 2016 - Wiley Online Library
In this study, 18 new 3‐benzylquinoxalinyl hydrazones bearing carbohydrate moiety and
their corresponding triazoloquinoxalines were synthesized in order to investigate their …

Synthesis of quinoxalines using Gum Arabic as a nontoxic metal-free biocatalyst at room temperature in aqueous media

SA Fazeli-Attar, BBF Mirjalili - Environmental Chemistry Letters, 2018 - Springer
In the present study, Gum Arabic was used as a metal-free biocatalyst in the synthesis of
quinoxaline derivatives through condensation of 1, 2-diamines and 1, 2-dicarbonyl …

Porous catalytic systems in the synthesis of bioactive heterocycles and related compounds

E Pérez-Mayoral, AJ López-Peinado - Green synthetic approaches for …, 2021 - Elsevier
Synthesis of heterocyclic compounds is an important issue in organic chemistry. A large
variety of natural products such as hormones, vitamins, and even antibiotics essential for …

Sustainable approaches towards the synthesis of quinoxalines

PS Jadhavar, D Kumar, P Purohit, BV Pipaliya… - … Chemistry: Synthesis of …, 2014 - Springer
The quinoxaline (Qx) nucleus is present in various bioactive molecules. Thus, synthesis of
Qxs continues to draw the attention of synthetic organic/medicinal chemists. The …