ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

Currently, many people worldwide suffer from metabolic diseases caused by heredity and
external factors, such as diet. One of the symptoms of metabolic diseases is abnormal lipid …

Rice is a major dietary source of inorganic arsenic (As), a nonthreshold carcinogen.
Reducing As accumulation in rice grain is of critical importance for food safety. In the present …

Multidrug resistance (MDR) proteins belonging to the ATP-Binding Cassette (ABC)
transporter group play a crucial role in the export of cytotoxic drugs across cell membranes …

Purpose Pseudoxanthoma elasticum (PXE) is a heritable disorder affecting elastic fibers in
the skin, eyes, and cardiovascular system. It is caused by biallelic pathogenic variants in the …

Background Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic
mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment …

Pseudoxanthoma elasticum (PXE) is a complex autosomal recessive disease caused by
mutations of ABCC6 transporter and characterized by ectopic mineralization of soft …

Bivalve mollusks can accumulate diarrheic shellfish poisoning (DSP) toxins through filter-
feeding, but they exhibit some resistance to the toxins. Previous studies have suggested that …

The ATP-binding cassette sub-family C member 6 transporter (ABCC6) is an ATP dependent
transporter mainly found in the basolateral plasma membrane of hepatic and kidney cells …

ABCC6, belonging to sub-family C of ATP-binding cassette transporter, is an ATP-
dependent transporter mainly present in the basolateral plasma membrane of hepatic and …