During the last decades, tremendous chemical efforts have been dedicated to design
monovalent inhibitors of carbohydrate‐processing enzymes, with comparatively few rewards …

NMDA receptors are part of the ionotropic glutamate receptor family, and are crucial for
neurotransmission and memory. At the cellular level, the effects of activating these receptors …

Fluorescent light-up aptamers (FLAPs) have emerged as valuable tools to visualize RNAs,
but are mostly limited by their poor brightness, low photostability, and high fluorescence …

Many multidomain proteins contain disordered linkers that regulate interdomain contacts,
and thus the effective concentrations that govern intramolecular reactions. Effective …

INTRODUCTION Animal behavior is mediated by molecular, cellular, and circuit
components of the brain. However, because many proteins are broadly expressed, it has …

Herein we present the synthesis, and biological evaluation of new Schiff bases incorporating
(2‑hydroxy-5-methylbenzaldehyde sulfisoxazole (S2M-S1) and 2‑hydroxy-5 …

Kinase specificity is crucial to the fidelity of signaling pathways, yet many pathways use the
same kinases to achieve widely different effects. Specificity arises in part from the enzymatic …

DC-SIGN antagonists were designed combining one selective monovalent glycomimetic
ligand with trivalent dendrons separated by a rigid core of controlled length. The design …

Kinesin-mediated cargo transport is required for many cellular functions and plays a key role
in pathological processes. Structural information on how kinesins recognize their cargoes is …

Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular
targets, have been recently exploited for enzyme inhibition showing interesting properties …