Investigating protein–ligand interactions by solution nuclear magnetic resonance spectroscopy
W Becker, KC Bhattiprolu, N Gubensäk… - …, 2018 - Wiley Online Library
Protein–ligand interactions are of fundamental importance in almost all processes in living
organisms. The ligands comprise small molecules, drugs or biological macromolecules and …
organisms. The ligands comprise small molecules, drugs or biological macromolecules and …
Transient protein–protein interactions visualized by solution NMR
Proteins interact with each other to establish their identities in cell. The affinities for the
interactions span more than ten orders of magnitude, and KD values in μM–mM regimen are …
interactions span more than ten orders of magnitude, and KD values in μM–mM regimen are …
Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase
Abstract N6-methyladenosine (m6A), a ubiquitous RNA modification, is installed by METTL3-
METTL14 complex. The structure of the heterodimeric complex between the …
METTL14 complex. The structure of the heterodimeric complex between the …
Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition
A polyubiquitin comprises multiple covalently linked ubiquitins and recognizes myriad
targets. Free or bound to ligands, polyubiquitins are found in different arrangements of …
targets. Free or bound to ligands, polyubiquitins are found in different arrangements of …
Preferential interactions of a crowder protein with the specific binding site of a native protein complex
Nonspecific binding of crowder proteins with functional proteins is likely prevalent in vivo, yet
direct quantitative evidence, let alone residue-specific information, is scarce. Here we …
direct quantitative evidence, let alone residue-specific information, is scarce. Here we …
Pulsed-field nuclear magnetic resonance: Status and prospects
High-magnetic-field nuclear magnetic resonance (NMR) has manifested itself as an
indispensable tool in modern scientific research in the fields of physics, chemistry, materials …
indispensable tool in modern scientific research in the fields of physics, chemistry, materials …
HBFormer: a single-stream framework based on hybrid attention mechanism for identification of human-virus protein–protein interactions
L Zhang, S Wang, Y Wang, T Zhao - Bioinformatics, 2024 - academic.oup.com
Motivation Exploring human-virus protein–protein interactions (PPIs) is crucial for unraveling
the underlying pathogenic mechanisms of viruses. Limitations in the coverage and …
the underlying pathogenic mechanisms of viruses. Limitations in the coverage and …
ClsC protein encoded by a stress-responsive operon in Escherichia coli functions as a trans-acting activator of RNase III
K Kim, H Cho - International Journal of Biological Macromolecules, 2025 - Elsevier
RNase III, an endoribonuclease that cleaves double-stranded RNAs (dsRNAs), significantly
impacts Escherichia coli (E. coli) adaptation by regulating global RNA gene expression …
impacts Escherichia coli (E. coli) adaptation by regulating global RNA gene expression …
Integrating non-NMR distance restraints to augment NMR depiction of protein structure and dynamics
Nuclear magnetic resonance (NMR) structure refinement is inherently integrative. The
refinement incorporates a multitude of experimental data and minimizes the difference …
refinement incorporates a multitude of experimental data and minimizes the difference …
Noise decomposition principle in a coherent feed-forward transcriptional regulatory loop
R Gui, Q Liu, Y Yao, H Deng, C Ma, Y Jia… - Frontiers in Physiology, 2016 - frontiersin.org
Coherent feed-forward loops exist extensively in realistic biological regulatory systems, and
are common signaling motifs. Here, we study the characteristics and the propagation …
are common signaling motifs. Here, we study the characteristics and the propagation …