Synthetic molecular probes, chemosensors, and nanosensors used in combination with
innovative assay protocols hold great potential for the development of robust, low-cost, and …

Fragment based drug discovery has long been used for the identification of new ligands and
interest in targeted covalent inhibitors has continued to grow in recent years, with high …

Rapid bond-forming reactions are crucial for efficient bioconjugation. We describe a simple
and practical strategy for facilitating ultra-rapid electrophilic cysteine arylation. Using a …

Glutathione (GSH) plays a vital role in many physiological processes, and its abnormal
levels have been found to be associated with several diseases. In contrast to traditional …

Fluoroindoles as an important structural scaffold are widely existing in many bioactive or
therapeutic agents. Despite their potential usefulness, efficient constructions of 2 …

Kinetics of the reactions of isocyanates, isothiocyanates, carbodiimides, carbon disulfide,
and carbon dioxide with carbanions or enamines (reference nucleophiles) have been …

Glutathione (GSH) as an important endogenous antioxidant plays key role in maintaining the
intracellular redox homeostasis and the imbalance of GSH level in cells is highly implicated …

The concept of nucleophilicity is at the basis of most transformations in chemistry.
Understanding and predicting the relative reactivity of different nucleophiles is therefore of …

The reactivities of cyclic enones and α, β-unsaturated lactones were characterized by
following the kinetics of their reactions with colored carbon-centered reference nucleophiles …

In the last few decades, growing numbers of fluorescent probes have been developed to
detect intracellular GSH. However, the majority of probes for GSH were irreversible without …