Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Mammalian iron homeostasis must be meticulously regulated so that this essential element
is available for use, but at the same time prevented from promoting the formation of toxic …

NGAL (neutrophil gelatinase-associated lipocalin) also known as lcn2 or siderochalin is
constitutively expressed in myelocytes and stored in specific granules of neutrophils. It is …

Although progress in imaging and genetics allow for a noninvasive diagnosis of most cases
of genetic iron overload, liver pathology remains often useful (1) to assess prognosis by …

Iron overload diseases of genetic origin are an ever changing world, due to major advances
in genetics and molecular biology. Five major categories are now established: HFE-related …

Iron overload disease due to mutations in ferroportin has a dominant inheritance and a
variable clinical phenotype, such that some patients show early Küpffer cell iron loading and …

Most cases of genetic hemochromatosis (GH) are associated with the HFE C282Y/C282Y (p.
Cys282Tyr/p. Cys282Tyr) genotype in white populations. The symptoms expressed by …

Identification of new players in iron metabolism, such as hepcidin, which regulates
ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron …

The cross-talk which has taken place in recent years between clinicians and scientists has
resulted in a greater understanding of iron metabolism with the discovery of new iron-related …