Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Misuse and overuse of antibiotics have contributed in the last decades to a phenomenon
known as antibiotic resistance which is currently considered one of the principal threats to …

Due to the alarming developing rate of multidrug-resistant bacterial pathogens, the
development and modification of antimicrobial peptides (AMPs) are unprecedentedly active …

The transition of antimicrobial peptides (AMPs) from the laboratory to market has been
severely hindered by their instability toward proteases in biological systems. In the present …

Peptide drugs hold great potential for the treatment of infectious diseases due to their
unconventional mechanisms of action, biocompatibility, biodegradability and ease of …

Non-natural amino acids are increasingly used as building blocks in the development of
peptide-based drugs as they expand the available chemical space to tailor function, half-life …

Antibiotic resistance is one of the greatest challenges of our time. This global health problem
originated from a paucity of truly effective antibiotic classes and an increased incidence of …

Some antimicrobial peptides have been shown to be able to inhibit the proliferation of
cancer cell lines. Various strategies for treating cancers with active peptides have been …

The golden era of antibiotics, heralded by the discovery of penicillin, has long been
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …

In molecular cancer therapeutics only 10% of known cancer gene products are targetable
with current pharmacological agents. Major oncogenic drivers, such as MYC and KRAS …