Genetic control of gonadal sex determination and development
Sex determination is the process by which the bipotential gonads develop as either testes or
ovaries. With two distinct potential outcomes, the gonadal primordium offers a unique model …
ovaries. With two distinct potential outcomes, the gonadal primordium offers a unique model …
The regulation of Sox9 expression in the gonad
N Gonen, R Lovell-Badge - Current topics in developmental biology, 2019 - Elsevier
The bipotential nature of cell types in the early developing gonad and the process of sex
determination leading to either testis or ovary differentiation makes this an interesting system …
determination leading to either testis or ovary differentiation makes this an interesting system …
The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming
RE Lindeman, MW Murphy, KS Agrimson… - Nucleic acids …, 2021 - academic.oup.com
Mammalian sexual development commences when fetal bipotential progenitor cells adopt
male Sertoli (in XY) or female granulosa (in XX) gonadal cell fates. Differentiation of these …
male Sertoli (in XY) or female granulosa (in XX) gonadal cell fates. Differentiation of these …
CBX2 is required to stabilize the testis pathway by repressing Wnt signaling
SA Garcia-Moreno, YT Lin, CR Futtner… - PLoS …, 2019 - journals.plos.org
XX and XY fetal gonads are initially bipotential, poised between the ovary and testis fate.
Multiple lines of evidence suggest that commitment to testis fate requires the repression of …
Multiple lines of evidence suggest that commitment to testis fate requires the repression of …
Dissecting human gonadal cell lineage specification and sex determination using a single-cell RNA-seq approach
Gonadal somatic cells are the main players in gonad development and are important for sex
determination and germ cell development. Here, using a time-series single-cell RNA …
determination and germ cell development. Here, using a time-series single-cell RNA …
In vitro cellular reprogramming to model gonad development and its disorders
During embryonic development, mutually antagonistic signaling cascades determine
gonadal fate toward a testicular or ovarian identity. Errors in this process result in disorders …
gonadal fate toward a testicular or ovarian identity. Errors in this process result in disorders …
Sex determination without sex chromosomes
C Weber, B Capel - … Transactions of the Royal Society B, 2021 - royalsocietypublishing.org
With or without sex chromosomes, sex determination is a synthesis of many molecular
events that drives a community of cells towards a coordinated tissue fate. In this review, we …
events that drives a community of cells towards a coordinated tissue fate. In this review, we …
Becoming female: ovarian differentiation from an evolutionary perspective
Differentiation of the bipotential gonadal primordium into ovaries and testes is a common
process among vertebrate species. While vertebrate ovaries eventually share the same …
process among vertebrate species. While vertebrate ovaries eventually share the same …
FOXL2 interaction with different binding partners regulates the dynamics of ovarian development
The transcription factor FOXL2 is required in ovarian somatic cells for female fertility.
Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to …
Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to …
TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway
Gonadal sexual fate in mammals is determined during embryonic development and must be
actively maintained in adulthood. In the mouse ovary, oestrogen receptors and FOXL2 …
actively maintained in adulthood. In the mouse ovary, oestrogen receptors and FOXL2 …