Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
[HTML][HTML] Ageing and Parkinson's disease: why is advancing age the biggest risk factor?
A Reeve, E Simcox, D Turnbull - Ageing research reviews, 2014 - Elsevier
As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …
disease, the health, social and economic impact resulting from Parkinson's disease will …
New roles for mitochondrial proteases in health, ageing and disease
Recent advances in mitochondrial biology have revealed the high diversity and complexity
of proteolytic enzymes that regulate mitochondrial function. We have classified mitochondrial …
of proteolytic enzymes that regulate mitochondrial function. We have classified mitochondrial …
A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance
BC Hammerling, RH Najor, MQ Cortez… - Nature …, 2017 - nature.com
Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal.
The currently recognized mechanism for disposal of mitochondria is autophagy, where …
The currently recognized mechanism for disposal of mitochondria is autophagy, where …
[HTML][HTML] A comprehensive overview of the complex role of oxidative stress in aging, the contributing environmental stressors and emerging antioxidant therapeutic …
E Iakovou, M Kourti - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Introduction: Aging is a normal, inevitable, irreversible and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …
driven by internal and external factors. Oxidative stress, that is the imbalance between …
Mitochondrial dysfunction in Parkinson's disease
Q Hu, G Wang - Translational neurodegeneration, 2016 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease, which is
characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta …
characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta …
Apoptotic proteins with non-apoptotic activity: expression and function in cancer
V Shoshan-Barmatz, T Arif, A Shteinfer-Kuzmine - Apoptosis, 2023 - Springer
Apoptosis is a process of programmed cell death in which a cell commits suicide while
maintaining the integrity and architecture of the tissue as a whole. Apoptosis involves …
maintaining the integrity and architecture of the tissue as a whole. Apoptosis involves …
M itochondrial DNA and primary mitochondrial dysfunction in P arkinson's disease
In 1979, it was observed that parkinsonism could be induced by a toxin inhibiting
mitochondrial respiratory complex I. This initiated the long‐standing hypothesis that …
mitochondrial respiratory complex I. This initiated the long‐standing hypothesis that …
Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences
AN Malik, A Czajka, P Cunningham - Mitochondrion, 2016 - Elsevier
Background Mitochondria contain an extra-nuclear genome in the form of mitochondrial
DNA (MtDNA), damage to which can lead to inflammation and bioenergetic deficit. Changes …
DNA (MtDNA), damage to which can lead to inflammation and bioenergetic deficit. Changes …
Intraneuronal β-amyloid impaired mitochondrial proteostasis through the impact on LONP1
Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer's disease
(AD). Mitochondrial proteostasis regulated by chaperones and proteases in each …
(AD). Mitochondrial proteostasis regulated by chaperones and proteases in each …