Twenty-five years have passed since the discovery of cyclic dimeric (3′→ 5′) GMP (cyclic
di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial …

Two-component signal transduction systems enable bacteria to sense, respond, and adapt
to a wide range of environments, stressors, and growth conditions. In the prototypical two …

We report on a microfluidic particle-separation device that makes use of the asymmetric
bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on …

Pole development is coordinated with the Caulobacter crescentus cell cycle by two-
component signaling proteins. We show that an unusual response regulator, PleD, is …

Two-component signal transduction systems, comprised of histidine kinases and their
response regulator substrates, are the predominant means by which bacteria sense and …

This report presents full-genome evidence that bacterial cells use discrete transcription
patterns to control cell cycle progression. Global transcription analysis of synchronized …

Dividing cells must coordinate cell cycle events to ensure genetic stability. Here we identify
an essential two-component signal transduction protein that controls multiple events in the …

The complete genome sequence of Caulobacter crescentus was determined to be
4,016,942 base pairs in a single circular chromosome encoding 3,767 genes. This …

The global transcriptional regulator CtrA controls multiple events in the Caulobacter cell
cycle, including the initiation of DNA replication, DNA methylation, cell division, and flagellar …

Caulobacter crescentus is an aquatic Gram-negative alphaproteobacterium that undergoes
multiple changes in cell shape, organelle production, subcellular distribution of proteins, and …