Reperfusion of ischemic intestine leads to a sequence of events that paradoxically results in
tissue injury. Reperfusion following short periods of ischemia causes alterations in …

The accumulation of leukocytes in inflamed tissue results from adhesive interactions
between leukocytes and endothelial cells within the microcirculation. These adhesive …

Skeletal muscle ischemia and reperfusion is now recognized as one form of acute
inflammation in which activated leukocytes play a key role. Although restoration of flow is …

Reperfusion of ischemic organs can result in tissue injury that is manifested as
microvascular and parenchymal cell dysfunction. Reactive oxygen metabolites and …

Ischemia and reperfusion (I/R) are thought to play an important role in the pathophysiology
of ischemic diseases of the heart. It is now well appreciated that leukocyte–endothelial cell …

Significance: The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil
bactericidal proteins and is stored in large amounts inside azurophilic granules of …

This study aimed to examine whether an elevated activity of heme oxygenase (HO)-1 in the
tissue attenuates endothelial cell–leukocyte interactions microvessels in vivo. When rats …

Intestinal mucosal damage in the inflammatory bowel diseases (IBD) Crohn's disease (CD)
and ulcerative colitis (UC) involves reactive oxygen metabolites (ROMs). ROMs are …

Reactive oxygen species (ROS) are generated by many different cells. Singlet oxygen (1O
2) and a reaction product of it, excited carbonyls (C O*), are important ROS. 1O 2 and C …

Hepatic ischemia and reperfusion elicits an immune response that lacks a microbial
constituent yet poses a potentially lethal threat to the host. In this sterile setting, the immune …