Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …

Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one
of the fastest growing public health problems in the world. It is characterized by …

Background Diabetes is presently classified into two main forms, type 1 and type 2 diabetes,
but type 2 diabetes in particular is highly heterogeneous. A refined classification could …

Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Genetics plays a role, to a greater or lesser extent, in all diseases. Variations in our DNA and
differences in how that DNA functions (alone or in combinations), alongside the environment …

The American Diabetes Association, JDRF, the European Association for the Study of
Diabetes, and the American Association of Clinical Endocrinologists convened a research …

Abstract The Research Domain Criteria (RDoC) paradigm was launched 10 years ago as a
superior approach for investigation of mental illness. RDoC conceptualizes normal human …