The immunopathophysiology of endometriosis

LK Symons, JE Miller, VR Kay, RM Marks… - Trends in molecular …, 2018 - cell.com
Endometriosis is a chronic, inflammatory, estrogen-dependent disease characterized by the
growth of endometrial tissue outside of the uterine cavity. Although the etiology of …

Pathogenesis of endometriosis: New insights into prospective therapies

R Kapoor, CA Stratopoulou, MM Dolmans - International journal of …, 2021 - mdpi.com
Endometriosis is a female reproductive disorder characterized by growth of uterine cells and
tissue in distant sites. Around 2–10% of women experience this condition during …

Inflammatory mediators and pain in endometriosis: a systematic review

N Machairiotis, S Vasilakaki, N Thomakos - Biomedicines, 2021 - mdpi.com
Background: pain is one of the main symptoms of endometriosis and it has a deleterious
effect on a patients' personal and social life. To date, the clinical management of pain …

Anti-inflammatory cytokines in endometriosis

WJ Zhou, HL Yang, J Shao, J Mei, KK Chang… - Cellular and molecular …, 2019 - Springer
Although the pathogenesis of endometriosis is not fully understood, it is often considered to
be an inflammatory disease. An increasing number of studies suggest that differential …

[HTML][HTML] Understanding the impact of uterine fibroids on human endometrium function

A Navarro, MV Bariani, Q Yang… - Frontiers in cell and …, 2021 - frontiersin.org
Uterine fibroids (leiomyomas) are the most common benign gynecological tumors in women
of reproductive age worldwide. They cause heavy menstrual bleeding, usually leading to …

The role of peritoneal macrophages in endometriosis

TN Ramírez-Pavez, M Martínez-Esparza… - International journal of …, 2021 - mdpi.com
Endometriosis is an estrogen-dependent gynecological disorder, defined as the growth of
endometrial stromal cells and glands at extrauterine sites. Endometriotic lesions are more …

Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology

A McCallion, Y Nasirzadeh, H Lingegowda… - Frontiers in …, 2022 - frontiersin.org
Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the
growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in …

[HTML][HTML] Systematic development and optimization of inhalable pirfenidone liposomes for non-small cell lung cancer treatment

V Parvathaneni, NS Kulkarni, SK Shukla, PT Farrales… - Pharmaceutics, 2020 - mdpi.com
Non-small cell lung cancer (NSCLC) is a global disorder, treatment options for which remain
limited with resistance development by cancer cells and off-target events being major …

[HTML][HTML] IL-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis

JE Miller, H Lingegowda, LK Symons, O Bougie… - JCI insight, 2021 - ncbi.nlm.nih.gov
Chronic inflammation and localized alterations in immune cell function are suspected to
contribute to the progression of endometriosis and its associated symptoms. In particular, the …

Platelets and regulatory T cells may induce a type 2 immunity that is conducive to the progression and fibrogenesis of endometriosis

F Xiao, X Liu, SW Guo - Frontiers in immunology, 2020 - frontiersin.org
Endometriosis is a hormonal disease, as well as a chronic inflammatory disease. While
various immune cells are documented to be involved in endometriosis, there is a wanton …