Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …

Abstract Machine learning, and especially deep learning, is rapidly gaining acceptance and
clinical usage in a wide range of image analysis applications and is regarded as providing …

We study how the topology of a data set M= Ma∪ Mb⊆ ℝ d, representing two classes a and
b in a binary classification problem, changes as it passes through the layers of a well-trained …

Topological data analysis (TDA) is a collection of powerful tools that can quantify shape and
structure in data in order to answer questions from the data's domain. This is done by …

The increasing amount of data in biomechanics research has greatly increased the
importance of developing advanced multivariate analysis and machine learning techniques …

The rise of technologies that simultaneously measure thousands of data points represents
the heart of systems biology. These technologies have had a huge impact on the discovery …

Chromosomal translocations that generate in-frame oncogenic gene fusions are notable
examples of the success of targeted cancer therapies,,. We have previously described gene …

Acute cardiorespiratory breathlessness accounts for one in eight of all emergency
hospitalizations. Early, noninvasive diagnostic testing is a clinical priority that allows rapid …

Rationale: Stratification of asthma at the molecular level, especially using accessible
biospecimens, could greatly enable patient selection for targeted therapy. Objectives: To …

Background Primary ciliary dyskinesia (PCD) is a heterogeneous inherited disorder caused
by mutations in approximately 50 cilia-related genes. PCD genotype–phenotype …