The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators
by its versatility of functions and mechanisms of action, which include the regulation of …

In patients with age-related macular degeneration (AMD), the crucial retinal pigment
epithelial (RPE) cells are characterized by mitochondria that are structurally and functionally …

Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically
heterogeneous diseases characterized by the progressive degeneration of the retina …

Background Age-related macular degeneration (AMD) leads to gradual central vision loss
and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti …

Inflammasomes are intracellular protein complexes that form in response to a variety of
stress signals and that serve to catalyze the proteolytic conversion of pro-interleukin-1β and …

Circadian rhythm and the molecules involved in it, such as melanopsin and melatonin, play
an important role in the eye to regulate the homeostasis and even to treat some ocular …

Melanosomes are specialized membrane-bound organelles that synthesize and organize
melanin, ultimately providing color to the skin, hair, and eyes. Disorders in melanogenesis …

Environmental pollution, inadequate eating habits and unhealthy lifestyles have led to a
tremendous increase in ocular diseases worldwide. Given the costly treatments that are …

Age related macular degeneration (AMD) is the main cause of legal blindness in developed
countries. It is a multifactorial disease in which a combination of genetic and environmental …

Central serous chorioretinopathy (CSC) is a vision‐threatening disease with no validated
treatment and unclear pathogenesis. It is characterized by dilation and leakage of choroidal …