Polycystic ovary syndrome (PCOS) is the most common ovarian disorder associated with
androgen excess in women, which justifies the growing interest of endocrinologists. Great …

In the circulation, testosterone and other sex hormones are bound to binding proteins, which
play an important role in regulating their transport, distribution, metabolism, and biological …

Objective Health and lifestyle factors are associated with variations in serum testosterone
levels in ageing men. However, it remains unclear how age-related changes in testosterone …

Importance Testosterone use in older men is increasing, but its long-term effects on
progression of atherosclerosis are unknown. Objective To determine the effect of …

The human microbiome contains a vast array of microbes and genes that show greater
complexity than the host's own karyome; the functions of many of these microbes are …

A wealth of observational studies show that low testosterone is associated with insulin
resistance and with an increased risk of diabetes and the metabolic syndrome. Experimental …

The single most significant risk factor for testosterone deficiency in men is obesity. The
pathophysiological mechanisms involved in male obesity-related secondary hypogonadism …

Sex hormone binding globulin (SHBG) is a glycoprotein composed of two 373‐amino‐acid
subunits. The SHBG gene and a promotor region have been identified. The SHBG receptor …

Background Low total testosterone (TT) and sex hormone-binding globulin (SHBG)
concentrations have been associated with the metabolic syndrome (MetS) in men, but the …

Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D),
are now a widespread pandemic in the developed world. These pathologies show sex …