Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …

Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

Background Concurrent treatment with temozolomide and radiotherapy followed by
maintenance temozolomide is the standard of care for patients with newly diagnosed …

Barrier tissue immune responses are regulated in part by nociceptors. Nociceptor ablation
alters local immune responses at peripheral sites and within draining lymph nodes (LNs) …

Vascular development in the mammalian retina is a paradigm for CNS vascular
development in general, and its study is revealing fundamental mechanisms that explain the …

A precise communication between the nervous and the vascular systems is crucial for
proper formation and function of the central nervous system (CNS). Interestingly, this …

Adipose tissue comprises adipocytes and many other cell types that engage in dynamic
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …

Vascular endothelial growth factors (VEGFs) have been shown to participate in
atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis …

Several biomaterials can be obtained from human blood. Some are used for clinical
indications requiring a high content in fibrinogen, while others are used because they …

Inflammation is a common component of acute injuries of the central nervous system (CNS)
such as ischemia, and degenerative disorders such as Alzheimer's disease. Glial cells play …