Over the recent years, much has been unraveled about the pro-inflammatory properties of
various mitochondrial molecules once they are leaving the mitochondrial compartment. On …

Neutrophils are well known for their role in infection and inflammatory disease and are first
responders at sites of infection or injury. Platelets have an established role in hemostasis …

Significance: Mitochondria, vital cellular power plants to generate energy, are involved in
immune responses. Mitochondrial damage-associated molecular patterns (DAMPs) are …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

There is now a large body of evidence that platelets are central actors of inflammatory
reactions. Indeed, platelets play a significant role in a variety of inflammatory diseases …

Extracellular ATP and related nucleotides promote a wide range of pathophysiological
responses via activation of cell surface purinergic P2 receptors. Almost every cell type …

Besides their functions in the haemostatic process and in thrombus formation after an
endothelial injury, blood platelets also take part in the processes of inflammation and tissue …

The manifestation of platelet 'satallitism'around neutrophils in whole blood is a long
acknowledged phenomenon [1]. Circulating platelet–neutrophil complexes (PNC) occur in a …

Besides their role in hemostasis, platelets are involved in inflammatory and immunological
processes, and we hypothezise that platelet activation may play an immunopathogenetic …