Abstract The Rotterdam Study is a population-based cohort study, started in 1990 in the
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …

Abstract Machine learning (ML) has become increasingly popular in almost all scientific
disciplines, including human genetics. Owing to challenges related to sample collection and …

Purpose of Review GWAS, as a largely correlational analysis, requires in vitro or in vivo
validation. Zebrafish (Danio rerio) have many advantages for studying the genetics of …

Background While previous research has established an association between inflammatory
bowel disease (IBD) and osteoporosis (OP), the nature of this association in different …

Abstract Bone Health Index (BHI) has been proposed as a useful instrument for assessing
bone health in children. However, its relationship with fracture risk remains unknown. We …

Over 1,100 independent signals have been identified with genome-wide association studies
(GWAS) for bone mineral density (BMD), a key risk factor for mortality-increasing fragility …

Here, we conducted genome-wide association studies (GWAS) of dual-energy X-ray
absorptiometry (DXA)-derived bone mineral density (BMD) traits at 11 skeletal sites, within …

Machine learning (ML) has revolutionized analytical strategies in almost all scientific
disciplines including human genetics and genomics. Due to challenges in sample collection …

Genetics has played an increasingly important role in patient management over recent
decades, with innovations improving the care of diseases ranging from breast cancer to …

Purpose The etiopathogenesis of coronal nonsyndromic craniosynostosis (cNCS), a
congenital condition defined by premature fusion of 1 or both coronal sutures, remains …