Translational challenges and opportunities in biofilm science: a BRIEF for the future

CJ Highmore, G Melaugh, RJ Morris, J Parker… - npj Biofilms and …, 2022 - nature.com
Biofilms are increasingly recognised as a critical global issue in a multitude of industries
impacting health, food and water security, marine sector, and industrial processes resulting …

Experimental models of hepatocellular carcinoma—a preclinical perspective

A Blidisel, I Marcovici, D Coricovac, F Hut… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is characterized by a broad molecular
and genetic heterogeneity, which makes it a challenging subject in terms of the underlying …

Modeling Crevicular Fluid Flow and Host‐Oral Microbiome Interactions in a Gingival Crevice‐on‐Chip

H Makkar, Y Zhou, KS Tan, CT Lim… - Advanced Healthcare …, 2023 - Wiley Online Library
Gingival crevice and gingival crevicular fluid (GCF) flow play a crucial role at the gingiva‐
oral microbiome interface which contributes toward maintaining the balance between …

Superhydrophobic synergistic antibacterial ZrO2-based surfaces with tertiary hierarchical structures fabricated by femtosecond laser texturing and surface modification

J Ruan, L Huang, H Zhang, Z Wang, L Wang… - Journal of Alloys and …, 2024 - Elsevier
Zirconia (ZrO 2) is a hard and brittle dental implant material without anti-infective property.
This work reports the preparation of a tertiary micro-nano hierarchical structure on a ZrO 2 …

[HTML][HTML] Dual-functionalized titanium by ultrafast laser texturing to enhance human gingival fibroblasts adhesion and minimize Porphyromonas gingivalis colonization

S Papa, A Abou Khalil, H Hamzeh-Cognasse… - Applied Surface …, 2022 - Elsevier
Dental implant failure is primarily due to peri-implantitis, a consequence of bacterial
penetration causing implant loosening. Beyond supporting the implant, the adhesion of …

Modeling periodontal host-microbe interactions using vascularized gingival connective tissue equivalents

H Makkar, CT Lim, KS Tan, G Sriram - Biofabrication, 2023 - iopscience.iop.org
Gingival connective tissue and its vasculature play a crucial role in the host's immune
response against the periodontal microbiome and serve as a bridge between the oral and …

A call for action to the biomaterial community to tackle antimicrobial resistance

TJ Hall, VM Villapún, O Addison, MA Webber… - Biomaterials …, 2020 - pubs.rsc.org
The global surge of antimicrobial resistance (AMR) is a major concern for public health and
proving to be a key challenge in modern disease treatment, requiring action plans at all …

Microfluidic organ-on-chip systems for periodontal research: advances and future directions

G Sriram, H Makkar - Frontiers in Bioengineering and Biotechnology, 2025 - frontiersin.org
Advances in tissue engineering and microfluidic technologies have enabled the
development of sophisticated in vitro models known as organ-on-a-chip (OoC) or …

Vegetal compounds as sources of prophylactic and therapeutic agents in dentistry

RA Milutinovici, D Chioran, R Buzatu, I Macasoi… - Plants, 2021 - mdpi.com
Dental pathology remains a global health problem affecting both children and adults. The
most important dental diseases are dental caries and periodontal pathologies. The main …

Label-Free Monitoring of Coculture System Dynamics: Probing Probiotic and Cancer Cell Interactions via Infrared Spectroscopic Imaging

Y Jeong, PH Hsieh, Y Phal, R Bhargava… - Analytical …, 2024 - ACS Publications
Evaluating the dynamic interaction of microorganisms and mammalian cells is challenging
due to the lack of suitable platforms for examining interspecies interactions in biologically …