Cell homeostasis is maintained in all organisms by the constant adjustment of cell
constituents and organisation to account for environmental context. Fine-tuning of the …

Yeast cells are equipped with different nutrient signaling pathways that enable them to
sense the availability of various nutrients and adjust metabolism and growth accordingly …

Enveloped viruses assemble and bud from the host cell membranes. Any role of cortical
actin in these processes have often been a source of debate. Here, we assessed if cortical …

The mechanistic target of rapamycin complex 1 (mTORC1) is part of the amino acid sensing
machinery that becomes activated on the endolysosomal surface in response to nutrient …

Abstract Aurora Kinase A (AURKA) is an oncogenic kinase with major roles in mitosis, but
also exerts cell cycle-and kinase-independent functions linked to cancer. Therefore, control …

Tyrosine kinase inhibitors represented by sorafenib are the first‐line treatment for
hepatocellular carcinoma (HCC), but the low response rate of HCC patient has become a …

In multinuclear and multicellular filamentous fungi little is known about how mRNAs
encoding secreted enzymes are transcribed and localized spatiotemporally. To better …

Alzheimer's disease (AD) is a neurodegenerative disease with a complex etiology
influenced by confounding factors such as genetic polymorphisms, age, sex, and race …

Proteome adaptation is key to cells surviving stresses. Increased translation of proteasome
assembly chaperones (PACs) is critical for increasing proteasome assembly and cell …

Plants delicately regulate endogenous auxin levels through the coordination of transport,
biosynthesis, and inactivation, which is crucial for growth and development. While it is well …