How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …

Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …

The exterior of the mammalian brain—the cerebral cortex—has a conserved layered
structure whose thickness varies little across species. However, selection pressures over …

A major cause of the cerebral cortex expansion that occurred during evolution is the
increase in subventricular zone (SVZ) progenitors. We found that progenitors in the outer …

The cerebral cortex of large mammals undergoes massive surface area expansion and
folding during development. Specific mechanisms to orchestrate the growth of the cortex in …

Gyrification is the process by which the brain undergoes changes in surface morphology to
create sulcal and gyral regions. The period of greatest development of brain gyrification is …

Cortical folding, or gyrification, coincides with several important developmental processes.
The folded shape of the human brain allows the cerebral cortex, the thin outer layer of …

In the developing human brain, the cortical sulci formation is a complex process starting from
14 weeks of gestation onward. The potential influence of underlying mechanisms (genetic …

The development of the nervous system has so far, to a large extent, been considered in the
context of biochemistry, molecular biology and genetics. However, there is growing …

During human brain development, the cerebral cortex undergoes substantial folding,
leading to its characteristic highly convoluted form. Folding is necessary to accommodate …