Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of
protective immunity to future variants, but we lack insights into immune responses before or …

A hypoxic state is critical to the metastatic and invasive characteristics of cancer. Numerous
pathways play critical roles in cancer maintenance, many of which include noncoding RNAs …

Sex differences in autoimmunity and infection suggest that a better understanding of
molecular sex differences will improve the diagnosis and treatment of immune-related …

Immunosuppression renders the host increased susceptible for secondary infections. It is
becoming increasingly clear that not only bacterial sepsis, but also respiratory viruses with …

Viral infections induce a conserved host response distinct from bacterial infections. We
hypothesized that the conserved response is associated with disease severity and is distinct …

Purpose The inappropriate use of antimicrobials, especially in acute respiratory infections
(ARIs), is largely driven by difficulty distinguishing bacterial, viral, and noninfectious …

Background Influenza infects tens of millions of people every year in the USA. Other than
notable risk groups, such as children and the elderly, it is difficult to predict what …

Identification of host transcriptional response signatures has emerged as a new paradigm
for infection diagnosis. For clinical applications, signatures must robustly detect the …

Objective To better define the immunopathogenesis of COVID-19, the present study aims to
characterize the early immune responses to SARS-CoV-2 infection in household contacts of …

Respiratory infections cause significant morbidity and mortality, yet it is unclear why some
individuals succumb to severe disease. In patients hospitalized with avian A (H7N9) …