Quantification and regulation of pathway metabolites is crucial for optimization of microbial
production bioprocesses. Genetically encoded biosensors provide the means to couple …

Allosteric transition, defined as conformational changes induced by ligand binding, is one of
the fundamental properties of proteins. Allostery has been observed and characterized in …

The construction and assembly of artificial allosteric protein switches into information and
energy processing networks connected to both biological and non-biological systems is a …

Enzymes are the proteins responsible for the catalysis of life. Enzymes sharing a common
ancestor as defined by sequence and structure similarity are grouped into families and …

The reversible regulation of catalytic activity is a feature found in natural enzymes which is
not commonly observed in artificial catalytic systems. Here, we fabricate an artificial …

The concept of a “power stroke”—a free‐energy releasing conformational change—appears
in almost every textbook that deals with the molecular details of muscle, the flagellar rotor …

Sensory photoreceptors not only control diverse adaptive responses in Nature, but as light-
regulated actuators they also provide the foundation for optogenetics, the non-invasive and …

Allostery is the functional change at one site on a protein caused by a change at a distant
site. In order for the benefits of allostery to be taken advantage of, both for basic …

Allosteric protein switches are key controllers of information and energy processing in living
organisms and are desirable engineered control tools in synthetic systems. Here we present …

In living organisms, enzyme catalysis takes place in aqueous media with extraordinary
spatiotemporal control and precision. The mechanistic knowledge of enzyme catalysis and …