The genetic material in human cells is continuously exposed to a wide variety of insults that
can induce different DNA lesions. To maintain genomic stability and prevent potentially …

ABSTRACT ADP-ribose is a versatile modification that plays a critical role in diverse cellular
processes. The addition of this modification is catalyzed by ADP-ribosyltransferases, among …

Circular RNAs (circRNAs) are a recently discovered class of RNAs derived from protein-
coding genes that have important biological and pathological roles. They are formed …

OGG1 is the DNA glycosylase responsible for the removal of the oxidative lesion 8-
oxoguanine (8-oxoG) from DNA. The recognition of this lesion by OGG1 is a complex …

Live-cell and high-resolution fluorescence microscopy are powerful tools to study the
organization and dynamics of DNA double-strand break repair foci and specific repair …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a crucial member of the PARP family,
which modifies targets through ADP-ribosylation and plays key roles in a variety of biological …

Abstract Performing accurate Fluorescence Correlation Spectroscopy (FCS) measurements
in cells can be challenging due to cellular motion or other intracellular processes. In this …

Defining the molecular mechanisms by which genome maintenance proteins dynamically
associate with and process DNA is essential to understand the potential avenues by which …

Background Ovarian cancer is one of women's malignancies with the highest mortality
among gynecological cancers. Paclitaxel is used in first-line ovarian cancer chemotherapy …

Abstract Poly (ADP-ribosylation)(PARylation) by poly (ADP-ribose) polymerases (PARPs) is
a highly regulated process that consists of the covalent addition of polymers of ADP-ribose …