Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Abstract Two-pore-domain K+ (K2P) channel subunits are made up of four transmembrane
segments and two pore-forming domains that are arranged in tandem and function as either …

Activation of mechanosensitive ion channels by physical force underlies many physiological
processes including the sensation of touch, hearing and pain,,,,. TRAAK (also known as …

TREK-1 is the most studied background K2P channel. Its main role is to control cell
excitability and maintain the membrane potential below the threshold of depolarization …

The mammalian family of two-pore domain K+ (K2P) channel proteins are encoded by 15
KCNK genes and subdivided into six subfamilies on the basis of sequence similarities …

Two-pore-domain K+(K 2P) channels are a diverse and highly regulated superfamily of
channels that are thought to provide baseline regulation of membrane excitability. Of these …

The ability to sense and respond to mechanical forces is essential for life and cells have
evolved a variety of systems to convert physical forces into cellular signals. Within this …

The versatility of neuronal electrical activity is largely conditioned by the expression of
different structural and functional classes of K+ channels. More than 80 genes encoding the …

Two-pore domain potassium (K2P) channels are expressed in cells throughout the body and
give rise to leak potassium currents which control the excitability of these cells. Although not …

Cerebral ischemia is a multi-faceted neurodegenerative pathology that causes cellular injury
to neurons within the central nervous system. In light of the underlying mechanisms being …