The ability of cells to transmit bioactive molecules to recipient cells and the extracellular
environment is a fundamental requirement for both normal physiology and disease …

The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS
superfamily of small GTPases and is involved in a wide variety of physiological processes …

Activating mutations in Gαq proteins, which form the α subunit of certain heterotrimeric G
proteins, drive uveal melanoma oncogenesis by triggering multiple downstream signaling …

Tumour-derived microvesicles (TMVs) comprise a class of extracellular vesicles released
from tumour cells that are now understood to facilitate communication between the tumour …

Mechanical force modulates development, influences tissue homeostasis, and contributes to
disease. Forces sculpt tissue-level behaviors and direct cell fate by engaging …

The importance of canonical and non-canonical Wnt signal transduction cascades in
embryonic development and tissue homeostasis is well recognized. The aberrant activation …

The Wnt signaling pathways play pivotal roles in carcinogenesis. Modulation of the cell-
surface abundance of Wnt receptors is emerging as an important mechanism for regulating …

Cardamonin (CD), an active chalconoid, has shown potent anticancer effects in preclinical
studies; however, the effect and underlying mechanism of CD for the treatment of triple …

Using gene expression data to enhance our knowledge of control networks relevant to
cancer biology and therapy is a challenging but urgent task. Based on the premise that …

Extracellular vesicles (EVs) are a heterogeneous population of small membrane vesicles
released by all types of cells in both physiological and pathological conditions. EVs shuttle …