Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …

Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

Microglia are the primary mediators of the immune defense system of the CNS and are
integral to the subsequent inflammatory response. The role of microglia in the injured CNS is …

Traumatic injury to the central nervous system results in the disruption of the blood
brain/spinal barrier, followed by the invasion of cells and other components of the immune …

Strategies for spinal cord injury repair are limited, in part, by poor drug delivery techniques.
A novel drug delivery system (DDS) is being developed in our laboratory that can provide …

After traumatic spinal cord injury, functional deficits increase as axons die back from the
center of the lesion and the glial scar forms. Axonal dieback occurs in two phases: an initial …

Background: Glioblastoma multiforme is the most aggressive brain tumor with poor
prognosis and an average survival of 1-2 years. Animal models that simulate the features of …

Spinal cord injury results in a life‐disrupting series of deleterious interconnected
mechanisms encompassed by the primary and secondary injury. These events are mediated …

Central neuropathic pain (CNP) developing after spinal cord injury (SCI) is described by the
region affected: above-level, at-level and below-level pain occurs in dermatomes rostral …

Susceptibility to neuroinflammatory disease is influenced in part by genetics. Recent data
indicate that survival of traumatized neurons is strain dependent and influenced by …