Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …

Optical microscopy has for centuries been a key tool to study living cells with minimum
invasiveness. The advent of single molecule techniques over the past two decades has …

Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …

Cell surface receptors govern a multitude of signalling pathways in multicellular organisms.
In plants, prominent examples are the receptor kinases FLS2 and BRI1, which activate …

Phagocytosis is a specialized process that enables cellular ingestion and clearance of
microbes, dead cells and tissue debris that are too large for other endocytic routes. As such …

Habitually professional phagocytes, including macrophages, eradicate microbial invaders
from the human body without overt signs of infection. Despite this, there exist select bacteria …

Phagocytosis is initiated by lateral clustering of receptors, which in turn activates Src-family
kinases (SFKs). Activation of SFKs requires depletion of tyrosine phosphatases from the …

Aims Retention of low-density lipoprotein (LDL) cholesterol beneath the arterial endothelium
initiates an inflammatory response culminating in atherosclerosis. Since the overlying …