Guanine nucleotide–binding proteins regulate a variety of processes, including sensual
perception, protein synthesis, various transport processes, and cell growth and …

Eukaryotic cells create internal order by using protein motors to transport molecules and
organelles along cytoskeletal tracks. Recent genomic and functional studies suggest that …

The microtubule-based kinesin motors and actin-based myosin motors generate motions
associated with intracellular trafficking, cell division, and muscle contraction. Early studies …

Sequences and available structures were compared for all the widely distributed
representatives of the P-loop GTPases and GTPase-related proteins with the aim of …

Motility often plays a decisive role in the survival of species. Five systems of motility have
been studied in depth: those propelled by bacterial flagella, eukaryotic actin polymerization …

The cytoskeleton is a system of intracellular filaments crucial for cell shape, division, and
function in all three domains of life. The simple cytoskeletons of prokaryotes show surprising …

Members of the diverse superfamily of AAA+ proteins are molecular machines responsible
for a wide range of essential cellular processes. In this review we summarise structural and …

Over the past two years, it has become evident that there is an unexpected link between
nuclear pore complex structure and dynamics, nucleocytoplasmic transport and …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

Dynamin, best studied for its role in clathrin-mediated endocytosis, is the prototypical
member of a family of multidomain GTPases involved in fission and remodeling of multiple …