Quinoline is a versatile pharmacophore, a privileged scaffold and an outstanding fused
heterocyclic compound with a wide range of pharmacological prospective such as …

Introduction Cancer has been identified as one of the leading causes of death worldwide.
The biological target of some anticancer agents is topoisomerase I, an enzyme involved in …

Developing new asymmetric auto‐tandem catalysis processes, especially in a divergent
manner, is highly attractive but extremely challenging. Presented herein is a palladium …

Derivatization of azaarenes can create molecules of biological importance, but reductive
functionalization of weakly reactive azaarenes remains a challenge. Here the authors show …

A cornerstone in drug discovery is the development of strategies to provide privileged small
molecules with specific structural and stereochemical complexity, allowing access to new …

Introduction Topoisomerases are important targets for therapeutic improvement in the
treatment of some diseases, including cancer. Inhibitors and poisons of topoisomerase I can …

An efficient synthetic methodology for the preparation of 3-amino 1, 5-dihydro-2 H-pyrrol-2-
ones through a multicomponent reaction of amines, aldehydes, and pyruvate derivatives is …

Abstract The synthesis of 1, 8-naphthyridine derivatives fused with other heterocycles, such
as chromenes and quinolines, as well as their behaviour as topoisomerase I inhibitors is …

We disclose the first accomplishment of the azo-Povarov reaction involving Sc (OTf) 3-
catalyzed [4+ 2] annulations of N-carbonyl aryldiazenes with cyclopentadiene in chloroform …

Cancer is spreading worldwide and is one of the leading causes of death. The use of
existing chemotherapeutic agents is frequently limited due to side effects. As a result, it is …