It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs
and secrete in normal and in pathological conditions several molecules, called, respectively …

Sarcopenia is an age-related clinical complaint characterized by the progressive
deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) is …

Introduction Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic
liver disease worldwide, but underlying mechanisms are not fully understood. In recent …

Background: Irisin as an exercise-induced myokine was proposed to improve bone health.
This study investigated the role of serum irisin (s-irisin) in patients with osteoporosis (OP) …

Pathological states marked by oxidative stress and systemic inflammation frequently
compromise the functional capacity of muscular cells. This progressive decline in muscle …

Maintaining systemic homeostasis requires the coordination of different organs and tissues
in the body. Our bodies rely on complex inter-organ communications to adapt to …

Irisin is a myokine synthesized by skeletal muscle, which performs key actions on whole-
body metabolism. Previous studies have hypothesized a relationship between irisin and …

Muscle weakness has been recognized as a hallmark feature of vitamin D deficiency for
many years. Until recently, the direct biomolecular effects of vitamin D on skeletal muscle …

Irisin is a peptide secreted by skeletal muscle following exercise that plays an important role
in bone metabolism. Numerous experiments in vitro and in mouse models have shown that …

Purpose Diabetes is a metabolic disorder characterized by chronic hyperglycemia due to
insulin deficiency and/or loss of its action. Diabetic myopathy causes functional limitations in …