Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and
hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON …

Ron, the tyrosine kinase receptor for the Macrophage-stimulating protein, is involved in cell
dissociation, motility, and matrix invasion. ΔRon, a constitutively active isoform that confers …

Stromal fibroblasts regulate epithelial cell behavior through direct and indirect cell–cell
interactions. To clarify the role of TGF-β signaling in stromal fibroblasts during mammary …

The cause of metastasis remains elusive despite vast information on cancer cells. We posit
that cancer cell fusion with macrophages or other migratory bone marrow‐derived cells …

The type 1 parathyroid hormone receptor (PTHR1) binds, with equal affinity, two ligands with
distinct biological functions: PTH, the major peptide hormone controlling calcium …

The Ron receptor is a member of the Met family of cell surface receptor tyrosine kinases and
is primarily expressed on epithelial cells and macrophages. The biological response of Ron …

A better understanding of tumor metastasis requires development of animal models that
authentically reproduce the metastatic process. By modifying an existing mouse model of …

The pathogenesis of Hodgkin lymphoma (HL) is still largely unknown. Based on a search for
footprints of pathogenetic mechanisms in global RNA expression data of Hodgkin/Reed …

Prolactin hormone (PRL) is well characterized as a terminal differentiation factor for
mammary epithelial cells and as an autocrine growth/survival factor in breast cancer cells …