In an effort to uncover systematic learnings that can be applied to improve compound
survival, an analysis was performed on data from Phase II decisions for 44 programs at …

Personalized medicine, in modern drug therapy, aims at a tailored drug treatment
accounting for inter-individual variations in drug pharmacology to treat individuals effectively …

Mechanistic PKPD models are now advocated not only by academic and industrial
researchers, but also by regulators. A recent development in this area is based on the …

The role of pharmacokinetics (PK) in drug discovery is to support the optimisation of the
absorption, distribution, metabolism and excretion (ADME) properties of lead compounds …

The discovery and development of new drugs seems to be an inefficient process, since too
few new chemical entities (NCEs) successfully make it to the market. Because one of the …

Issues of parameter identifiability of routinely used pharmacodynamics models are
considered in this paper. The structural identifiability of 16 commonly applied …

Infection persists as one of the leading global causes of morbidity and mortality, with
particular burden at the extremes of age and in populations who are immunocompromised …

Highlights•Implementation of quantitative pharmacology strategy to discovery drug
projects.•Building dedicated preclinical M&S capability.•Developing a companywide …

Static in vitro cell culture studies cannot capture the dynamic concentration profiles of drugs,
nutrients, and other factors that cells experience in physiological systems. This limits the …

BACKGROUND AND PURPOSE A series of novel non‐peptide corticotropin releasing factor
type‐1 receptor (CRF1) antagonists were found to display varying degrees of …