The molecular and cellular effect of homocysteine metabolism imbalance on human health

H Škovierová, E Vidomanová, S Mahmood… - International journal of …, 2016 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in
methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia, is …

Homocysteine-induced endothelial dysfunction

WKC Lai, MY Kan - Annals of Nutrition and Metabolism, 2015 - karger.com
This review discussed and in particular emphasis the potential cellular pathways and the
biological processes involved that lead to homocysteine-induced endothelial dysfunction, in …

Homocysteine‐lowering interventions for preventing cardiovascular events

AJ Marti-Carvajal, I Sola, D Lathyris… - Cochrane database of …, 2017 - cochranelibrary.com
Background Cardiovascular disease, which includes coronary artery disease, stroke and
peripheral vascular disease, is a leading cause of death worldwide. Homocysteine is an …

Importance of paraoxonase 1 (PON1) as an antioxidant and antiatherogenic enzyme in the cardiovascular complications of type 2 diabetes: Genotypic and phenotypic …

Y Shokri, A Variji, M Nosrati, A Khonakdar-Tarsi… - Diabetes research and …, 2020 - Elsevier
Oxidant–antioxidant imbalance is involved in the etiology of different diseases, including
cardiovascular diseases (CVDs), liver disorders, kidney diseases, cancers and diabetes …

Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets

Y Fu, X Wang, W Kong - British journal of pharmacology, 2018 - Wiley Online Library
Homocysteine is a sulphur‐containing non‐proteinogenic amino acid.
Hyperhomocysteinaemia (HHcy), the pathogenic elevation of plasma homocysteine as a …

Hyperhomocysteinemia and cardiovascular diseases.

R Guieu, J Ruf, G Mottola - Annales de biologie clinique, 2022 - search.ebscohost.com
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the
diet, but rather synthesized as an intermediate metabolite in the methionine cycle. Hcy is …

Homocysteine to hydrogen sulfide or hypertension

U Sen, PK Mishra, N Tyagi, SC Tyagi - Cell biochemistry and biophysics, 2010 - Springer
Hyperhomocysteinemia, an increased level of plasma homocysteine, is an independent risk
factor for the development of premature arterial fibrosis with peripheral and cerebro …

Hyperhomocysteinemia and cardiovascular disease: is the adenosinergic system the missing link?

F Paganelli, G Mottola, J Fromonot, M Marlinge… - International journal of …, 2021 - mdpi.com
The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …

B vitamins in stroke prevention: time to reconsider

JD Spence, Q Yi, GJ Hankey - The Lancet Neurology, 2017 - thelancet.com
B vitamin therapy lowers plasma total homocysteine concentrations, and might be a
beneficial intervention for stroke prevention; however, cyanocobalamin (a form of vitamin …

Homocystinuria diagnosis and management: it is not all classical

A Gerrard, C Dawson - Journal of Clinical Pathology, 2022 - jcp.bmj.com
Homocystinuria (HCU) refers to a group of inherited disorders of homocysteine metabolism
associated with high blood homocysteine concentration, thromboembolic tendency and …