Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, developing drugs for central nervous system (CNS) disorders remains the most …

Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic
diseases, share remarkably similar dysregulated pathways. Exposure to environmental …

Parkinson's disease (PD) is a progressive and incurable neurodegenerative disorder.
Although numerous genetic and environmental factors have been linked to the aetiology of …

Objective: To examine whether gene expression analysis of a large-scale Parkinson
disease (PD) patient cohort produces a robust blood-based PD gene signature compared to …

The epigenomic landscape of Parkinson's disease (PD) remains unknown. We performed a
genomewide DNA methylation and a transcriptome studies in induced pluripotent stem cell …

In the early sixties, a discussion started regarding the association between Parkinson's
disease (PD) and type II diabetes mellitus (T2DM). Today, this potential relationship is still a …

Environmental and genetic factors are likely to be involved in the pathogenesis of
Parkinson's disease (PD), the second most prevalent neurodegenerative disease among the …

Abstract Background The diagnosis of Parkinson's disease (PD) often remains a clinical
challenge. Molecular neuroimaging can facilitate the diagnostic process. The diagnostic …

CNS disorders are indications with a very high unmet medical needs, relatively smaller
number of available drugs, and a subpar satisfaction level among patients and caregiver …

A growing body of evidence indicates an increased risk for developing Parkinson's disease
(PD) among people with type 2 diabetes (T2DM). The relationship between the etiology and …