Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Peptides are known to possess a plethora of beneficial properties and activities:
antimicrobial, anticancer, anti-inflammatory or the ability to cross the blood–brain barrier are …

Uncontrolled microglial activation is pivotal to the pathogenesis of Parkinson's disease (PD),
which can secrete Cathepsin L (CTSL) to affect the survival of neurons in the PD patients; …

Oligomeric species populated during α-synuclein aggregation are considered key drivers of
neurodegeneration in Parkinson's disease. However, the development of oligomer-targeting …

Protein aggregation is responsible for several degenerative conditions in humans, and it is
also a bottleneck in industrial protein production and storage of biotherapeutics …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, yet
effective treatments able to stop or delay disease progression remain elusive. The …

Brain-derived neurotrophic factor (BDNF) is a neurotrophic protein that promotes neuronal
survival, increases neurotransmitter synthesis, and has potential therapeutic effects in …

This paper highlights how learnings from exploring assumptions can be strengthened by
taking an evolutionary approach to theory building and analysis. We discuss theory-driven …

Background Parkinson's disease (PD) is a prevalent neurodegenerative disorder
characterized by the progressive loss of dopaminergic neurons. This study aims to discover …

Oligomeric species populated during α-synuclein aggregation are considered key drivers of
neurodegeneration in Parkinson's disease. However, the development of oligomer-targeting …