Anti-inflammatory effect of muscle-derived interleukin-6 and its involvement in lipid metabolism

H Nara, R Watanabe - International journal of molecular sciences, 2021 - mdpi.com
Interleukin (IL)-6 has been studied since its discovery for its role in health and diseases. It is
one of the most important pro-inflammatory cytokines. IL-6 was reported as an exacerbating …

Functional role of skeletal muscle-derived interleukin-6 and its effects on lipid metabolism

W Lin, H Song, J Shen, J Wang, Y Yang… - Frontiers in …, 2023 - frontiersin.org
The detrimental impact of obesity on human health is increasingly evident with the rise in
obesity-related diseases. Skeletal muscle, the crucial organ responsible for energy balance …

COVID‐19 and neurodegeneration: The mitochondrial connection

CA Denaro, YI Haloush, SY Hsiao, JJ Orgera… - Aging …, 2022 - Wiley Online Library
There is still a significant lack of knowledge regarding many aspects of the etiopathology
and consequences of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

Nonalcoholic fatty liver disease, serum cytokines, and dementia among rural‐dwelling older adults in China: A population‐based study

Y Wang, Y Li, K Liu, X Han, Y Dong… - European journal of …, 2022 - Wiley Online Library
Background and purpose Little is known about whether nonalcoholic fatty liver disease
(NAFLD) is associated with dementia or the role of serum proinflammatory cytokines in the …

Interleukin-6 Facilitates Acute Myeloid Leukemia Chemoresistance via Mitofusin 1–Mediated Mitochondrial Fusion

D Hou, X Zheng, D Cai, R You, J Liu, X Wang… - Molecular Cancer …, 2023 - AACR
Acute myeloid leukemia (AML), an aggressive hematopoietic malignancy, exhibits poor
prognosis and a high recurrence rate largely because of primary and secondary drug …

Analysis of miRNAs profiles in serum of patients with steatosis and steatohepatitis

M Vulf, D Shunkina, A Komar, M Bograya… - Frontiers in Cell and …, 2021 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is emerging as one of the most common chronic
liver diseases worldwide, affecting 25% of the world population. In recent years, there has …

IL-6 Trans-Signaling Is Increased in Diabetes, Impacted by Glucolipotoxicity, and Associated with Liver Stiffness and Fibrosis in Fatty Liver Disease

A Gunes, C Schmitt, L Bilodeau, C Huet, A Belblidia… - Diabetes, 2023 - Am Diabetes Assoc
Many people living with diabetes also have nonalcoholic fatty liver disease (NAFLD).
Interleukin-6 (IL-6) is involved in both diseases, interacting with both membrane-bound …

Silibinin eliminates mitochondrial ROS and restores autophagy through IL6ST/JAK2/STAT3 signaling pathway to protect cardiomyocytes from doxorubicin-induced …

W Li, X Qu, X Kang, H Zhang, X Zhang, H Hu… - European Journal of …, 2022 - Elsevier
Growing evidence indicates that silibinin (SLB), a main component extracted from Chinese
herb Silybum marianum, can effectively antagonize doxorubicin (DOX) induced myocardial …

Effects of Shenling Baizhu powder on intestinal microflora metabolites and liver mitochondrial energy metabolism in nonalcoholic fatty liver mice

Z Yao, J Guo, B Du, L Hong, Y Zhu, X Feng… - Frontiers in …, 2023 - frontiersin.org
Background & purpose Non-alcoholic fatty liver disease (NAFLD) is characterised by the
excessive accumulation of triglycerides in the liver. Shenling Baizhu powder (SLBZP) is …

Interleukin-6 receptor blockade can increase the risk of nonalcoholic fatty liver disease: Indications from mendelian randomization

S Li, L Chen, G Lv - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Interleukin-6 receptor (IL-6R) blockade has been approved for inflammation-
associated diseases and whether it is effective in treating non-alcoholic fatty liver disease …