Control of Ph+ and additional chromosomal abnormalities in chronic myeloid leukemia by tyrosine kinase inhibitors

S Ansari, M Verma - Medical Oncology, 2023 - Springer
Chronic myeloid leukemia (CML) is a type of blood cancer that is known to affect
hematopoietic stem cells. The presence of the Philadelphia chromosome (Ph+) is the major …

Impact of additional chromosomal aberrations on the disease progression of chronic myelogenous leukemia

R Krishna Chandran, N Geetha, KM Sakthivel… - Frontiers in …, 2019 - frontiersin.org
The emergence of additional chromosomal abnormalities (ACAs) in Philadelphia
chromosome/BCR-ABL1 positive chronic myeloid leukemia (CML), is considered to be a …

[HTML][HTML] Imatinib Efficacy, Safety and Resistance in Iranian Patients with Chronic Myeloid Leukemia: A Review of Literature

A Amouei, N Daeian, SS Khezrnia… - … -Oncology and Stem …, 2021 - ncbi.nlm.nih.gov
Background: Imatinib is the gold standard in the treatment of chronic myeloid leukemia
(CML) patients. Resistance to imatinib is interfering with patients' responses and their …

Cytogenetic and epidemiological profile of chronic myeloid leukemia in Morocco

S Benchikh, SSG Charlène, A Bousfiha, L Razoki… - Annals of …, 2024 - Springer
Chronic myeloid leukemia (CML) is a neoplastic disease of genetic origin resulting from
clonal proliferation of hematopoietic stem cells (HSCs). The reciprocal translocation t (9; …

Effects of tyrosine kinase inhibitors for controlling Ph+ clone and additional clonal abnormalities in a chronic myeloid leukemia

BB Ganguly, S Mandal, D Banerjee… - Journal of Cancer …, 2022 - journals.lww.com
Purpose: The chronic myeloid leukemia (CML) is characterized by the presence of t (9;
22)(q34; q11) that results in chimerization of BCR and ABL genes on the rearranged …

[PDF][PDF] Patterns of chromosome abnormalities in a sample of Colombian patients with chronic myeloid leukemia.

A Largo-Peralta, M Rondón-Lagos… - Universitas …, 2023 - biogenetica.com.co
Abstract Chronic Myeloid Leukemia (CML) is characterized by the presence of the
Philadelphia (Ph) chromosome, resulting from a translocation between chromosomes 9 and …

Rare additional chromosomal abnormalities in acute promyelocytic leukaemia resulting in rapidly fatal disease: report of a case

AM Haidary, S Noor, S Noor, M Ahmad… - …, 2022 - Wiley Online Library
Background Acute promyelocytic leukaemia results from reciprocal translocation between
the long arms of chromosomes 15 and 17. This translocation leads to the formation of …

[PDF][PDF] A Novel Four-Way Translocation t (1; 3; 9; 22)(p36; p14; q34; q11. 2) involving Philadelphia Chromosome in a Patient of Chronic Myeloid Leukemia: A Case …

PK Varma, PJ Trivedi, DM Patel, MM Kazi, PS Patel - 2022 - meddocsonline.org
Abstract 90% of Chronic Myeloid Leukemia (CML) patients having Philadelphia (Ph)
chromosome or t (9; 22)(q34; q11. 2), and the remaining 5–8% of CML patients demonstrate …

Study of The Effect of Metformin on Plasminogen Activator Inhibitor-1 (PAI-1) and Some Biochemical and Blood Parameters in Patients with Type 2 Diabetes in …

KK Abdullah, MF Namik… - The Egyptian Journal of …, 2023 - ejhm.journals.ekb.eg
Background: Metformin, an anti-hyperglycemic drug, treats type 2 diabetes with diet. It
increases muscle glucose consumption, maintains blood levels, and does not cause severe …

[HTML][HTML] Plasma level of programmed death receptor ligand-1 and CD25 in chronic myeloid leukemia patients and their correlations with response to first-line therapy

NAR Jaleil, WM Abed - Medical Journal of Babylon, 2021 - journals.lww.com
Background: Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm that
is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a …