The healthy microbiome—what is the definition of a healthy gut microbiome?

F Shanahan, TS Ghosh, PW O'Toole - Gastroenterology, 2021 - Elsevier
Use of microbiome-based biomarkers in diagnosis, prognosis, risk profiling, and precision
therapy requires definition of a healthy microbiome in different populations. To determine …

Faecal microbiota transplantation for recurrent Clostridioides difficile infection: an updated systematic review and meta-analysis

SMD Baunwall, MM Lee, MK Eriksen, BH Mullish… - …, 2020 - thelancet.com
Background Faecal microbiota transplantation (FMT) is effective for recurrent Clostridioides
difficile infection (CDI), but inconsistent effect rates and uncertain evidence levels have …

Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology

A Khoruts, C Staley, MJ Sadowsky - Nature Reviews Gastroenterology & …, 2021 - nature.com
Faecal microbiota transplantation (FMT) has emerged as a remarkably successful treatment
for recurrent Clostridioides difficile infection that cannot be cured with antibiotics alone …

Recipient factors in faecal microbiota transplantation: one stool does not fit all

C Danne, N Rolhion, H Sokol - Nature Reviews Gastroenterology & …, 2021 - nature.com
Faecal microbiota transplantation (FMT) is a promising therapy for chronic diseases
associated with gut microbiota alterations. FMT cures 90% of recurrent Clostridioides difficile …

Phages in the gut ecosystem

M Zuppi, HL Hendrickson, JM O'Sullivan… - Frontiers in cellular and …, 2022 - frontiersin.org
Phages, short for bacteriophages, are viruses that specifically infect bacteria and are the
most abundant biological entities on earth found in every explored environment, from the …

Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model

TS Rasmussen, CMJ Mentzel, W Kot, JL Castro-Mejía… - Gut, 2020 - gut.bmj.com
Objective Development of obesity and type 2 diabetes (T2D) are associated with gut
microbiota (GM) changes. The gut viral community is predominated by bacteriophages …

Roles of the gut virome and mycobiome in faecal microbiota transplantation

S Lam, X Bai, AN Shkoporov, H Park, X Wu… - The Lancet …, 2022 - thelancet.com
Faecal microbiota transplantation (FMT) is an innovative approach to treat diseases that are
associated with gut dysbiosis, by transferring a healthy stool microbiota to a recipient with …

Capturing the environment of the Clostridioides difficile infection cycle

MK Schnizlein, VB Young - Nature Reviews Gastroenterology & …, 2022 - nature.com
Clostridioides difficile (formerly Clostridium difficile) infection is a substantial health and
economic burden worldwide. Great strides have been made over the past several years in …

The human gut phageome: origins and roles in the human gut microbiome

EM Townsend, L Kelly, G Muscatt, JD Box… - Frontiers in cellular …, 2021 - frontiersin.org
The investigation of the microbial populations of the human body, known as the microbiome,
has led to a revolutionary field of science, and understanding of its impacts on human …

The gut-liver axis in cholestatic liver diseases

A Blesl, V Stadlbauer - Nutrients, 2021 - mdpi.com
The gut-liver axis describes the physiological interplay between the gut and the liver and
has important implications for the maintenance of health. Disruptions of this equilibrium are …