Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency

SC Kim, SS Sekhon, WR Shin, G Ahn, BK Cho… - Molecular & cellular …, 2022 - Springer
Background mRNA vaccines hold great potential as therapeutic techniques against viral
infections due to their efficacy, safety, and large-scale production. mRNA vaccines offer …

mRNA vaccine: a potential therapeutic strategy

Y Wang, Z Zhang, J Luo, X Han, Y Wei, X Wei - Molecular cancer, 2021 - Springer
Abstract mRNA vaccines have tremendous potential to fight against cancer and viral
diseases due to superiorities in safety, efficacy and industrial production. In recent decades …

Factors underlying parental decisions about combination childhood vaccinations including MMR: a systematic review

KF Brown, JS Kroll, MJ Hudson, M Ramsay, J Green… - Vaccine, 2010 - Elsevier
Suboptimal childhood vaccination uptake results in disease outbreaks, and in developed
countries is largely attributable to parental choice. To inform evidence-based interventions …

Nanotechnology in vaccine delivery

LJ Peek, CR Middaugh, C Berkland - Advanced drug delivery reviews, 2008 - Elsevier
With very few adjuvants currently being used in marketed human vaccines, a critical need
exists for novel immunopotentiators and delivery vehicles capable of eliciting humoral …

Biodegradable polymers for protein and peptide drug delivery

WR Gombotz, DK Pettit - Bioconjugate chemistry, 1995 - ACS Publications
Over the past decade developments in the field of biotechnology have led to the cloning,
characterization, and commercial availability of many clinically useful proteins and peptides …

Poly (lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines

DT O'Hagan, M Singh, RK Gupta - Advanced Drug Delivery Reviews, 1998 - Elsevier
With the exception of the provision of clean water supplies, vaccination remains the most
successful public health intervention strategy for the control of infectious diseases. However …

Risky business: challenges in vaccine risk communication

LK Ball, G Evans, A Bostrom - Pediatrics, 1998 - publications.aap.org
Concern over vaccine safety has been a major determinant of immunization policy—from
passage of the Biologics Control Act in 1902 to the recent American Academy of Pediatrics …

Peptides conjugated to gold nanoparticles induce macrophage activation

NG Bastús, E Sánchez-Tilló, S Pujals, C Farrera… - Molecular …, 2009 - Elsevier
Macrophages that react against pathogenic organisms can also be activated with artificial
nanometric units consisting of gold nanoparticles (Au NPs) with a peptide coating. Using …

Vaccine risks: real, perceived and unknown

RT Chen - Vaccine, 1999 - Elsevier
As immunizations successfully reduce the incidence of their target diseases, the vaccine
community needs to evolve and recognize the increased relative prominence of vaccine …

cGAS‐STING pathway agonists are promising vaccine adjuvants

X Tian, J Ai, X Tian, X Wei - Medicinal Research Reviews, 2024 - Wiley Online Library
Adjuvants are of critical value in vaccine development as they act on enhancing
immunogenicity of antigen and inducing long‐lasting immunity. However, there are only a …