Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma
cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions …

Background Malaria and neglected communicable protozoa parasitic diseases, such as
leishmaniasis, and trypanosomiasis, are among the otherwise called diseases for neglected …

The huge global expansion of the COVID-19 pandemic caused by the novel SARS-corona
virus-2 is an extraordinary public health emergency. The unavailability of specific treatment …

Chagas disease still has no effective treatment option for all of its phases despite being
discovered more than 100 years ago. The development of commercial drugs has been …

Introduction Chagas disease (CD) affects~ 7 million people worldwide. Benznidazole (BZN)
and nifurtimox (NFX) are the only approved drugs for CD chemotherapy. Although both …

Covering: 2013–2022. Chemical diversification of natural products is an efficient way to
generate natural product-like compounds for modern drug discovery programs. Utilizing ring …

The current 2019–2021 marine pharmacology literature review provides a continuation of
previous reviews covering the period 1998 to 2018. Preclinical marine pharmacology …

Covering: 2000 up to 2021 Natural products are an important resource in drug discovery,
directly or indirectly delivering numerous small molecules for potential development as …

Pyronaridine (PYR) is an erythrocytic schizonticide with a potent antimalarial activity against
multidrug‐resistant Plasmodium. The drug is used in combination with artesunate for the …

This study accessed the potential antimalarial activity of triterpene glycoside of H. atra
through targeting orotidine 5‐monophosphate decarboxylase protein (PfOMPDC) in P …