The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Adverse cardiac remodeling after myocardial infarction (MI) causes structural and functional
changes in the heart leading to heart failure. The initial post-MI pro-inflammatory response …

Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism
against pathogens. However, the cellular self-protective mechanism against such potential …

Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin)
result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the …

Nutrient sensing and damage sensing are two fundamental processes in living organisms.
While hyperglycemia is frequently linked to diabetes-related vulnerability to microbial …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of
antiviral interferons and proinflammatory cytokines, which functions as the frontier of host …

Cytosolic double-stranded DNA surveillance by cyclic GMP-AMP synthase (cGAS)–
Stimulator of Interferon Genes (STING) signaling triggers cellular senescence, autophagy …

The Hippo pathway senses cellular conditions and regulates YAP/TAZ to control cellular and
tissue homeostasis, while TBK1 is central for cytosolic nucleic acid sensing and antiviral …