Embracing complexity in sepsis
AR Schuurman, PMA Sloot, WJ Wiersinga… - Critical Care, 2023 - Springer
Sepsis involves the dynamic interplay between a pathogen, the host response, the failure of
organ systems, medical interventions and a myriad of other factors. This together results in a …
organ systems, medical interventions and a myriad of other factors. This together results in a …
Development of new tuberculosis drugs: translation to regimen composition for drug-sensitive and multidrug-resistant tuberculosis
Tuberculosis (TB) kills more people than any other infectious disease. Challenges for
developing better treatments include the complex pathology due to within-host immune …
developing better treatments include the complex pathology due to within-host immune …
Spatial segregation and cooperation in radially expanding microbial colonies under antibiotic stress
Antibiotic resistance in microbial communities reflects a combination of processes operating
at different scales. In this work, we investigate the spatiotemporal dynamics of bacterial …
at different scales. In this work, we investigate the spatiotemporal dynamics of bacterial …
Stabilization of probabilistic finite automata based on semi-tensor product of matrices
Z Zhang, Z Chen, X Han, Z Liu - Journal of the Franklin Institute, 2020 - Elsevier
Probabilistic finite automata (PFAs) can exhibit a stochastic behavior, and its stabilization is
the basic and important problem in the control theory. In this paper, the stabilization with a …
the basic and important problem in the control theory. In this paper, the stabilization with a …
Model integration in computational biology: the role of reproducibility, credibility and utility
During the COVID-19 pandemic, mathematical modeling of disease transmission has
become a cornerstone of key state decisions. To advance the state-of-the-art host viral …
become a cornerstone of key state decisions. To advance the state-of-the-art host viral …
A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs
JM Cicchese, A Sambarey, D Kirschner… - Scientific Reports, 2021 - nature.com
Tuberculosis (TB) is the deadliest infectious disease worldwide. The design of new
treatments for TB is hindered by the large number of candidate drugs, drug combinations …
treatments for TB is hindered by the large number of candidate drugs, drug combinations …
Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas
Physiological abnormalities in pulmonary granulomas–pathological hallmarks of
tuberculosis (TB)–compromise the transport of oxygen, nutrients, and drugs. In prior studies …
tuberculosis (TB)–compromise the transport of oxygen, nutrients, and drugs. In prior studies …
A split-and-perturb decomposition of number-conserving cellular automata
This paper concerns d-dimensional cellular automata with the von Neumann neighborhood
that conserve the sum of the states of all their cells. These automata, called number …
that conserve the sum of the states of all their cells. These automata, called number …
Modelling the within-host spread of SARS-CoV-2 infection, and the subsequent immune response, using a hybrid, multiscale, individual-based model. Part I …
Individual responses to SARS-CoV-2 infection vary significantly, ranging from mild courses
of infection that do not require hospitalisation to the development of disease which not only …
of infection that do not require hospitalisation to the development of disease which not only …
Factors associated with treatment outcomes of patients with drug-resistant tuberculosis in China: A retrospective study using competing risk model
Z Li, K Lai, T Li, Z Lin, Z Liang, Y Du… - Frontiers in Public …, 2022 - frontiersin.org
Objectives Drug-resistant tuberculosis remains a serious public health problem worldwide,
particularly in developing countries, including China. This study determined treatment …
particularly in developing countries, including China. This study determined treatment …