Review of phage display: A jack-of-all-trades and master of most biomolecule display

BPC Song, ACW Ch'ng, TS Lim - International Journal of Biological …, 2024 - Elsevier
Phage display was first described by George P. Smith when it was shown that virus particles
were capable of presenting foreign proteins on their surface. The technology has paved the …

Engineering soluble T‐cell receptors for therapy

RA Robinson, C McMurran, ML McCully… - The FEBS …, 2021 - Wiley Online Library
Immunotherapy approaches that target peptide–human leukocyte antigen (pHLA)
complexes are becoming highly attractive because of their potential to access virtually all …

Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides

P Sharma, VVVR Marada, Q Cai… - Proceedings of the …, 2020 - National Acad Sciences
The potency of adoptive T cell therapies targeting the cell surface antigen CD19 has been
demonstrated in hematopoietic cancers. It has been difficult to identify appropriate targets in …

High-throughput stability screening of neoantigen/HLA complexes improves immunogenicity predictions

DT Blaha, SD Anderson, DM Yoakum, MV Hager… - Cancer immunology …, 2019 - AACR
Mutated peptides (neoantigens) from a patient's cancer genome can serve as targets for T-
cell immunity, but identifying which peptides can be presented by an MHC molecule and …

Rapid screening of TCR-pMHC interactions by the YAMTAD system

L Wang, X Lan - Cell Discovery, 2022 - nature.com
Personalized immunotherapy, such as cancer vaccine and TCR-T methods, demands rapid
screening of TCR-pMHC interactions. While several screening approaches have been …

Creation of a High‐Throughput Microfluidic Platform for Single‐Cell Transcriptome Sequencing of Cell‐Cell Interactions

J Qi, H Zhu, Y Li, X Guan, Y He, G Ren, Q Guo… - Small …, 2023 - Wiley Online Library
Cell‐cell interaction is one of the major modalities for transmitting information between cells
and activating the effects of functional cells. However, the construction of high‐throughput …

Application of phage display for T-cell receptor discovery

ACW Ch'ng, P Lam, M Alassiri, TS Lim - Biotechnology Advances, 2022 - Elsevier
The immune system is tasked to keep our body unharmed and healthy. In the immune
system, B-and T-lymphocytes are the two main components working together to stop and …

T‐cell receptor affinity in the age of cancer immunotherapy

MM Hoffmann, JE Slansky - Molecular carcinogenesis, 2020 - Wiley Online Library
The strength of the interaction between T‐cell receptors (TCRs) and their ligands,
peptide/major histocompatibility complex complexes (pMHCs), is one of the most frequently …

Tumor derived extracellular vesicles modulate gene expression in T cells

A Pando, C Schorl, LD Fast, JL Reagan - Gene, 2023 - Elsevier
Extracellular vesicles (EVs) are excreted from all cells in the human body and are
heterogeneous lipid bilayer particles containing proteins, RNA, DNA, and other cargo. T …

Engineering the T cell receptor for fun and profit: Uncovering complex biology, interrogating the immune system, and targeting disease

AM Rosenberg, BM Baker - Current opinion in structural biology, 2022 - Elsevier
T cell receptors (TCRs) orchestrate cellular immunity by recognizing peptide antigens bound
and presented by major histocompatibility complex (MHC) proteins. Due to the TCR's central …