Small RNA-based antimicrobial immunity

Z Guo, Y Li, SW Ding - Nature Reviews Immunology, 2019 - nature.com
Protection against microbial infection in eukaryotes is provided by diverse cellular and
molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus …

Mosquito innate immunity

A Kumar, P Srivastava, P Sirisena, SK Dubey, R Kumar… - Insects, 2018 - mdpi.com
Mosquitoes live under the endless threat of infections from different kinds of pathogens such
as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical …

SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

J Mu, J Xu, L Zhang, T Shu, D Wu, M Huang… - Science China Life …, 2020 - Springer
Coronaviruses (CoVs) are large enveloped non-segmented positive-strand RNA viruses that
broadly distribute among humans and other animal species, including bats, mice and birds …

Inflammation-induced, STING-dependent autophagy restricts Zika virus infection in the Drosophila brain

Y Liu, B Gordesky-Gold, M Leney-Greene… - Cell host & …, 2018 - cell.com
The emerging arthropod-borne flavivirus Zika virus (ZIKV) is associated with neurological
complications. Innate immunity is essential for the control of virus infection, but the innate …

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

YP Xu, Y Qiu, B Zhang, G Chen, Q Chen, M Wang… - Cell research, 2019 - nature.com
The re-emergence of Zika virus (ZIKV) in the Western Hemisphere has resulted in global
public health crisis since 2015. ZIKV preferentially infects and targets human neural …

Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges

H Kang, YJ Ga, SH Kim, YH Cho, JW Kim… - Journal of Biomedical …, 2023 - Springer
RNA has emerged as a revolutionary and important tool in the battle against emerging
infectious diseases, with roles extending beyond its applications in vaccines, in which it is …

Slicing and dicing viruses: antiviral RNA interference in mammals

PV Maillard, AG Van der Veen, EZ Poirier… - The EMBO …, 2019 - embopress.org
To protect against the harmful consequences of viral infections, organisms are equipped
with sophisticated antiviral mechanisms, including cell‐intrinsic means to restrict viral …

Crystal structure of the capsid protein from Zika virus

Z Shang, H Song, Y Shi, J Qi, GF Gao - Journal of molecular biology, 2018 - Elsevier
Recently, Zika virus (ZIKV) emerged as a global public health concern and is distinct from
other flaviviruses in many aspects, for example, causing transplacental infection, fetal …

RNA interference is essential to modulating the pathogenesis of mosquito-borne viruses in the yellow fever mosquito Aedes aegypti

GH Samuel, T Pohlenz, Y Dong… - Proceedings of the …, 2023 - National Acad Sciences
While it has long been known that the transmission of mosquito-borne viruses depends on
the establishment of persistent and nonlethal infections in the invertebrate host, specific …

Subgenomic flaviviral RNAs: What do we know after the first decade of research

A Slonchak, AA Khromykh - Antiviral research, 2018 - Elsevier
The common feature of flaviviral infection is the accumulation of abundant virus-derived
noncoding RNA, named flaviviral subgenomic RNA (sfRNA) in infected cells. This RNA …