The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators

LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions

A Abeysinghe, R Deshapriya, C Udawatte - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder and is identified as the most
common cause for dementia. Despite huge global economic burden and the impact on the …

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

K Rajasekhar, M Chakrabarti… - Chemical …, 2015 - pubs.rsc.org
Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

Molecular structure of Cu (II)-bound amyloid-β monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease

A Abelein, S Ciofi-Baffoni, C Mörman, R Kumar… - JACS Au, 2022 - ACS Publications
Metal ions, such as copper and zinc ions, have been shown to strongly modulate the self-
assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and elevated concentrations of …

Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance

E Atrián-Blasco, P Gonzalez, A Santoro, B Alies… - Coordination chemistry …, 2018 - Elsevier
Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

Amphiphilic distyrylbenzene derivatives as potential therapeutic and imaging agents for soluble and insoluble amyloid β aggregates in Alzheimer's disease

L Sun, HJ Cho, S Sen, AS Arango… - Journal of the …, 2021 - ACS Publications
Alzheimer's Disease (AD) is the most common neurodegenerative disease, and efficient
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …

Alzheimer's disease: How metal ions define β-amyloid function

KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Zinc, carnosine, and neurodegenerative diseases

M Kawahara, K Tanaka, M Kato-Negishi - Nutrients, 2018 - mdpi.com
Zinc (Zn) is abundantly present in the brain, and accumulates in the synaptic vesicles.
Synaptic Zn is released with neuronal excitation, and plays essential roles in learning and …

Analyzing amyloid beta aggregates with a combinatorial fluorescent molecular sensor

J Hatai, L Motiei, D Margulies - Journal of the American Chemical …, 2017 - ACS Publications
Different amyloid beta (Aβ) aggregates can be discriminated by a combinatorial fluorescent
molecular sensor. The unique optical fingerprints generated by the unimolecular analytical …

Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers

M Rana, AK Sharma - Metallomics, 2019 - academic.oup.com
The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ)
peptides has attracted a lot of attention in recent years due to its repercussions in …