RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …

To date, almost 2600 gene therapy clinical trials have been completed, are ongoing or have
been approved worldwide. Our database brings together global information on gene therapy …

Cancer immunotherapy is an emerging treatment strategy that modulates the immune
system to fight against cancer. Although several immunotherapeutic agents have been …

Abstract Near-infrared-II (NIR-II, 1000–1700 nm) light-triggered photothermal therapy (PTT)
has been regarded as a promising candidate for cancer treatment, but PTT alone often fails …

Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …

Non-viral vectors are simple in theory but complex in practice. Apart from intra cellular and
extracellular barriers, number of other challenges also needs to be overcome in order to …

The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …

Gene therapy is a promising new technique for treating many serious incurable diseases,
such as cancer and genetic disorders. The main problem limiting the application of this …

Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …

Due to improved phenotyping and genetic characterization, the field of 'incurable'and
'blinding'inherited retinal diseases (IRDs) has moved substantially forward. Decades of …